Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

ABSTRACT:

Background

Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome. The frequency and spectrum of genetic alterations in Ph-like ALL and its responsiveness to tyrosine kinase inhibition are undefined, especially in adolescents and adults.

Methods

We performed genomic profiling of 1725 patients with precursor B-cell ALL and detailed genomic analysis of 154 patients with Ph-like ALL. We examined the functional effects of fusion proteins and the efficacy of tyrosine kinase inhibitors in mouse pre-B cells and xenografts of human Ph-like ALL.

Results

Ph-like ALL increased in frequency from 10% among c

SUBMITTER: Roberts KG 

PROVIDER: S-EPMC4191900 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature