Hyperferritinaemia in dengue virus infected patients is associated with immune activation and coagulation disturbances.

ABSTRACT:

Background

During a dengue outbreak on the Caribbean island Aruba, highly elevated levels of ferritin were detected in dengue virus infected patients. Ferritin is an acute-phase reactant and hyperferritinaemia is a hallmark of diseases caused by extensive immune activation, such as haemophagocytic lymphohistiocytosis. The aim of this study was to investigate whether hyperferritinaemia in dengue patients was associated with clinical markers of extensive immune activation and coagulation disturbances.

Methodology/principal findings

Levels of ferritin, standard laboratory markers, sIL-2R, IL-18 and coagulation and fibrinolytic markers were determined in samples from patients with uncomplicated dengue in Aruba. Levels of ferritin were significantly increased in dengue patients c

SUBMITTER: van de Weg CA 

PROVIDER: S-EPMC4191960 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature