Unknown

Dataset Information

0

Group B streptococcal serine-rich repeat proteins promote interaction with fibrinogen and vaginal colonization.


ABSTRACT: Group B streptococcus (GBS) can cause severe disease in susceptible hosts, including newborns, pregnant women, and the elderly. GBS serine-rich repeat (Srr) surface glycoproteins are important adhesins/invasins in multiple host tissues, including the vagina. However, exact molecular mechanisms contributing to their importance in colonization are unknown. We have recently determined that Srr proteins contain a fibrinogen-binding region (BR) and hypothesize that Srr-mediated fibrinogen binding may contribute to GBS cervicovaginal colonization. In this study, we observed that fibrinogen enhanced wild-type GBS attachment to cervical and vaginal epithelium, and that this was dependent on Srr1. Moreover, purified Srr1-BR peptide bound directly to host cells, and peptide administration in vivo reduced GBS recovery from the vaginal tract. Furthermore, a GBS mutant strain lacking only the Srr1 "latching" domain exhibited decreased adherence in vitro and decreased persistence in a mouse model of GBS vaginal colonization, suggesting the importance of Srr-fibrinogen interactions in the female reproductive tract.

SUBMITTER: Wang NY 

PROVIDER: S-EPMC4192050 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Group B streptococcal serine-rich repeat proteins promote interaction with fibrinogen and vaginal colonization.

Wang Nai-Yu NY   Patras Kathryn A KA   Seo Ho Seong HS   Cavaco Courtney K CK   Rösler Berenice B   Neely Melody N MN   Sullam Paul M PM   Doran Kelly S KS  

The Journal of infectious diseases 20140311 6


Group B streptococcus (GBS) can cause severe disease in susceptible hosts, including newborns, pregnant women, and the elderly. GBS serine-rich repeat (Srr) surface glycoproteins are important adhesins/invasins in multiple host tissues, including the vagina. However, exact molecular mechanisms contributing to their importance in colonization are unknown. We have recently determined that Srr proteins contain a fibrinogen-binding region (BR) and hypothesize that Srr-mediated fibrinogen binding may  ...[more]

Similar Datasets

| S-EPMC10746215 | biostudies-literature
| S-EPMC5964516 | biostudies-literature
| S-EPMC7665007 | biostudies-literature
| S-EPMC9239048 | biostudies-literature
| S-EPMC9429885 | biostudies-literature
| S-EPMC8446444 | biostudies-literature
| S-EPMC8091692 | biostudies-literature
| S-EPMC3657335 | biostudies-literature
| S-EPMC6973325 | biostudies-literature
| S-EPMC6712506 | biostudies-literature