Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages.

ABSTRACT: Adipose tissue macrophage (ATM)-driven inflammation plays a key role in insulin resistance; however, factors activating ATMs are poorly understood. Using a proteomics approach, we show that markers of classical activation are absent on ATMs from obese humans but are readily detectable on airway macrophages of patients with cystic fibrosis, a disease associated with chronic bacterial infection. Moreover, treating macrophages with glucose, insulin, and palmitate-conditions characteristic of the metabolic syndrome-produces a "metabolically activated" phenotype distinct from classical activation. Markers of metabolic activation are expressed by proinflammatory ATMs in obese humans/mice and are positively correlated with adiposity. Metabolic activation is driven by independent proinflammatory a

SUBMITTER: Kratz M 

PROVIDER: S-EPMC4192131 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature