Re-evaluating cost effectiveness of universal meningitis vaccination (Bexsero) in England: modelling study.

ABSTRACT:

Objective

To use mathematical and economic models to predict the epidemiological and economic impact of vaccination with Bexsero, designed to protect against group B meningococcal disease, to help inform vaccine policy in the United Kingdom.

Design

Modelling study.

Setting

England.

Population

People aged 0-99.

Interventions

Incremental impact of introductory vaccine strategies simulated with a transmission dynamic model of meningococcal infection and vaccination including potential herd effects. Model parameters included recent evidence on the vaccine characteristics, disease burden, costs of care, litigation costs, and loss of quality of life from disease, including impacts on family and network members. The health impact of vaccination was assessed thr

SUBMITTER: Christensen H 

PROVIDER: S-EPMC4192138 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature