Interaction between thyroglobulin and ADAMTS16 in premature ovarian failure.

ABSTRACT:

Objective

The aim of the present study was to examine whether interactions between polymorphisms in the thyroglobulin and ADAM metallopeptidase with thrombospondin type 1 motif, 16 (ADAMTS16) genes are associated with the development of premature ovarian failure (POF).

Methods

A total of 75 patients with POF and 196 controls were involved in this study. We used a GoldenGate assay to genotype single nucleotide polymorphisms (SNPs). Logistic regression analysis was performed to identify POF-associated polymorphisms and synergistic interactions between polymorphisms in the thyroglobulin and ADAMTS16 genes.

Results

Single gene analyses using logistic regression analysis showed no significant association between polymorphisms in the two genes and POF. In the results from i

SUBMITTER: Pyun JA 

PROVIDER: S-EPMC4192452 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature