Structural characterization of genomes by large scale sequence-structure threading.

ABSTRACT:

Background

Using sequence-structure threading we have conducted structural characterization of complete proteomes of 37 archaeal, bacterial and eukaryotic organisms (including worm, fly, mouse and human) totaling 167,888 genes.

Results

The reported data represent first rather general evaluation of performance of full sequence-structure threading on multiple genomes providing opportunity to evaluate its general applicability for large scale studies. According to the estimated results the sequence-structure threading has assigned protein folds to more then 60% of eukaryotic, 68% of archaeal and 70% of bacterial proteomes.The repertoires of protein classes, architectures, topologies and homologous superfamilies (according to the CATH 2.4 classification) have been established fo

SUBMITTER: Cherkasov A 

PROVIDER: S-EPMC419331 | biostudies-literature | 2004 Apr

REPOSITORIES: biostudies-literature