The tumor microenvironment shapes lineage, transcriptional, and functional diversity of infiltrating myeloid cells.

ABSTRACT: Myeloid cells play important regulatory roles within the tumor environment by directly promoting tumor progression and modulating the function of tumor-infiltrating lymphocytes, and as such, they represent a potential therapeutic target for the treatment of cancer. Although distinct subsets of tumor-associated myeloid cells have been identified, a broader analysis of the complete myeloid cell landscape within individual tumors and also across different tumor types has been lacking. By establishing the developmental and transcriptomic signatures of infiltrating myeloid cells from multiple primary tumors, we found that tumor-associated macrophages (TAM) and tumor-associated neutrophils (TAN), while present within all tumors analyzed, exhibited strikingly different frequencies, gene expressio

SUBMITTER: Elpek KG 

PROVIDER: S-EPMC4194071 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature