Genome-wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co-activation.

ABSTRACT: Breast and ovarian cancer susceptibility genes BRCA1 and PALB2 have enigmatic roles in cellular growth and mammalian development. While these genes are essential for growth during early developmental programs, inactivation later in adulthood results in increased growth and formation of tumors, leading to their designation as tumor suppressors. We performed genome-wide analysis assessing their chromatin residence and gene expression responsiveness using high-throughput sequencing in breast epithelial cells. We found an intimate association between BRCA1 and PALB2 chromatin residence and genes displaying high transcriptional activity. Moreover, our experiments revealed a critical role for BRCA1 and, to a smaller degree, PALB2 in transcriptional responsiveness to NF-κB, a crucial mediator of

SUBMITTER: Gardini A 

PROVIDER: S-EPMC4194113 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature