Impact of general and central adiposity on ventricular-arterial aging in women and men.

ABSTRACT:

Objectives

The aim of this study was to assess the effects of central and general obesity measures on long-term longitudinal changes in ventricular-arterial mechanics.

Background

Obesity, female sex, and ventricular-arterial stiffening are associated with the development of heart failure with preserved ejection fraction. Fat distribution and chronic changes in body composition may affect longitudinal changes in LV properties, independent of arterial load.

Methods

In 1,402 subjects from a randomly selected, community-based population, comprehensive echo-Doppler echocardiography was performed at two examinations separated by 4 years. From this population, 788 subjects had paired data adequate for determining left ventricular end-systolic elastance (Ees), end-diastolic e

SUBMITTER: Wohlfahrt P 

PROVIDER: S-EPMC4194131 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature