MiR33 inhibition overcomes deleterious effects of diabetes mellitus on atherosclerosis plaque regression in mice.

ABSTRACT:

Rationale

Diabetes mellitus increases cardiovascular disease risk in humans and remains elevated despite cholesterol-lowering therapy with statins. Consistent with this, in mouse models, diabetes mellitus impairs atherosclerosis plaque regression after aggressive cholesterol lowering. MicroRNA 33 (miR33) is a key negative regulator of the reverse cholesterol transport factors, ATP-binding cassette transporter A1 and high-density lipoprotein, which suggested that its inhibition may overcome this impairment.

Objective

To assess the effects of miR33 inhibition on atherosclerosis regression in diabetic mice.

Methods and results

Reversa mice, which are deficient in the low-density lipoprotein receptor and in which hypercholesterolemia is reversed by conditional inactivatio

SUBMITTER: Distel E 

PROVIDER: S-EPMC4194153 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature