Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys.

ABSTRACT:

Background

In animal studies, organochlorine pesticide (OCP) exposure alters pubertal development; however, epidemiological data are limited and inconsistent.

Objective

To evaluate the associations of serum OCP concentrations [hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE)] with male pubertal onset.

Methods

In Chapaevsk, Russia, a town environmentally contaminated with OCPs, 350 8-9 year old boys with measured OCPs were enrolled during 2003-2005 and were followed annually for eight years. We evaluated three measures of pubertal onset: testicular volume (TV)>3 mL in either testis, or stage 2 or greater for genitalia (G2+), or pubic hair (P2+). We used multivariable interval-censored models to evaluate asso

SUBMITTER: Lam T 

PROVIDER: S-EPMC4194160 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature