Genetic and antigenic characterisation of serotype A FMD viruses from East Africa to select new vaccine strains.

ABSTRACT: Vaccine strain selection for emerging foot-and-mouth disease virus (FMDV) outbreaks in enzootic countries can be addressed through antigenic and genetic characterisation of recently circulating viruses. A total of 56 serotype A FMDVs isolated between 1998 and 2012, from Central, East and North African countries were characterised antigenically by virus neutralisation test using antisera to three existing and four candidate vaccine strains and, genetically by characterising the full capsid sequence data. A Bayesian analysis of the capsid sequence data revealed the viruses to be of either African or Asian topotypes with subdivision of the African topotype viruses into four genotypes (Genotypes I, II, IV and VII). The existing vaccine strains were found to be least cross-reactive (good matche

SUBMITTER: Bari FD 

PROVIDER: S-EPMC4194315 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature