Ontology highlight
ABSTRACT:
SUBMITTER: Lin Q
PROVIDER: S-EPMC4194897 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
The Journal of investigative dermatology 20140328 9
Stem cell therapy has shown promise in treating a variety of pathologies including skin wounds, but practical applications remain elusive. Here, we demonstrate that endogenous stem cell mobilization produced by AMD3100 and low-dose tacrolimus is able to reduce by 25% the time of complete healing of full-thickness wounds created by surgical excision. Equally important, healing was accompanied by reduced scar formation and regeneration of hair follicles. Searching for mechanisms, we found that AMD ...[more]