Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia.

ABSTRACT:

Background

Silent cerebral infarcts are the most common neurologic injury in children with sickle cell anemia and are associated with the recurrence of an infarct (stroke or silent cerebral infarct). We tested the hypothesis that the incidence of the recurrence of an infarct would be lower among children who underwent regular blood-transfusion therapy than among those who received standard care.

Methods

In this randomized, single-blind clinical trial, we randomly assigned children with sickle cell anemia to receive regular blood transfusions (transfusion group) or standard care (observation group). Participants were between 5 and 15 years of age, with no history of stroke and with one or more silent cerebral infarcts on magnetic resonance imaging and a neurologic examination

SUBMITTER: DeBaun MR 

PROVIDER: S-EPMC4195437 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature