Multiple omics uncovers host-gut microbial mutualism during prebiotic fructooligosaccharide supplementation.

ABSTRACT: Fructooligosaccharide (FOS), a prebiotic well known for its health-promoting properties, can improve the human gut ecosystem most likely through changes in its microbial composition. However, the detailed mechanism(s) of action of FOS in the modulation of the gut ecosystem remain(s) obscure. Traditional methods of profiling microbes and metabolites could barely show any significant features due to the existence of large interindividual differences, but our novel microbe-metabolite correlation approach, combined with faecal immunoglobulin A (IgA) measurements, has revealed that the induction of mucosal IgA by FOS supplementation correlated with the presence of specific bacteria. Furthermore, the metabolic dynamics of butyrate, L-phenylalanine, L-lysine and tyramine were positively correlate

SUBMITTER: Kato T 

PROVIDER: S-EPMC4195493 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature