Two-step self-assembly of liposome-multidomain peptide nanofiber hydrogel for time-controlled release.

ABSTRACT: Progress in self-assembly and supramolecular chemistry has been directed toward obtaining macromolecular assemblies with higher degrees of complexity, simulating the highly structured environment in natural systems. One approach to this type of complexity are multistep, multicomponent, self-assembling systems that allow approaches comparable to traditional multistep synthetic organic chemistry; however, only a few examples of this approach have appeared in the literature. Our previous work demonstrated nanofibrous mimics of the extracellular matrix. Here we demonstrate the ability to create a unique hydrogel, developed by stepwise self-assembly of multidomain peptide fibers and liposomes. The two-component system allows for controlled release of bioactive factors at multiple time points. T

SUBMITTER: Wickremasinghe NC 

PROVIDER: S-EPMC4195521 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature