Ontology highlight
ABSTRACT:
SUBMITTER: Sun K
PROVIDER: S-EPMC419567 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20040517 21
Graft-versus-host disease (GVHD) represents a major hurdle impeding the efficacy of allogeneic bone marrow transplantation (BMT). Bortezomib is a proteasome inhibitor that was recently approved for treatment of myeloma. We found that bortezomib potently inhibited in vitro mixed lymphocyte responses and promoted the apoptosis of alloreactive T cells. Bortezomib given at the time of allogeneic BMT in mice resulted in significant protection from acute GVHD. Reductions in GVHD-associated parameters ...[more]