A multimodal MRI study of the hippocampus in medication-naive children with ADHD: what connects ADHD and depression?

ABSTRACT: Children with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for developing depression. The neurobiological substrates that convey this risk remain poorly understood. On the basis of considerable data implicating hippocampal abnormalities in depressive disorders, we aimed to explore the relationship between the hippocampus and levels of depressive symptomatology in ADHD. We used magnetic resonance imaging (MRI) to examine the volumes and resting-state functional connectivity of the hippocampus in a sample of 32 medication naive children with ADHD (ages 6 - 13) and 33 age- and sex-matched healthy control (HC) participants. Compared with the HC participants, the participants with ADHD had (i) reduced volumes of the left hippocampus and (ii) reduced functional connectiv

SUBMITTER: Posner J 

PROVIDER: S-EPMC4195849 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature