Genome analysis of a major urban malaria vector mosquito, Anopheles stephensi.

ABSTRACT:

Background

Anopheles stephensi is the key vector of malaria throughout the Indian subcontinent and Middle East and an emerging model for molecular and genetic studies of mosquito-parasite interactions. The type form of the species is responsible for the majority of urban malaria transmission across its range.

Results

Here, we report the genome sequence and annotation of the Indian strain of the type form of An. stephensi. The 221 Mb genome assembly represents more than 92% of the entire genome and was produced using a combination of 454, Illumina, and PacBio sequencing. Physical mapping assigned 62% of the genome onto chromosomes, enabling chromosome-based analysis. Comparisons between An. stephensi and An. gambiae reveal that the rate of gene order reshuffling on the X chro

SUBMITTER: Jiang X 

PROVIDER: S-EPMC4195908 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature