Altered in vitro endothelial repair and monocyte migration in obstructive sleep apnea: implication of VEGF and CRP.

ABSTRACT:

Study objectives

Although obstructive sleep apnea (OSA) causes cardiovascular morbidities through atherosclerosis induced by inflammation and endothelial dysfunction, OSA patients exhibit elevated plasma vascular endothelial growth factor (VEGF), which may represent an adaptive response to intermittent hypoxia. The aims of this study were to investigate whether in vitro endothelial wound healing and monocyte migration are affected by patient serum, and to determine the implication of circulating factors (VEGF and C-reactive protein).

Patients

Serum was collected from healthy controls (HC), "healthy" OSA, and metabolic syndrome (MS) patients with or without OSA.

Measurements and results

Along with the presence of OSA and/or MS, both VEGF and hsCRP were significantly el

SUBMITTER: Briancon-Marjollet A 

PROVIDER: S-EPMC4196066 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature