CPEB1 modulates differentiation of glioma stem cells via downregulation of HES1 and SIRT1 expression.

ABSTRACT: Glioma stemness has been recognized as the most important reason for glioma relapse and drug resistance. Differentiation of glioma stem cells (GSCs) has been implicated as a novel approach to target recurrent glioma. However, the detailed molecular mechanism involved in the differentiation of GSCs has not yet been elucidated. This study identified CPEB1 as the key modulator that induces the differentiation of GSCs at the post-transcriptional level. Gain and loss of function experiments showed that CPEB1 expression reduced sphere formation ability and the expression of stemness markers such as Nestin and Notch. To elucidate the detailed molecular mechanism underlying the action of CPEB1, we investigated the interacting ribonome of the CPEB1 complex using a Ribonomics approach. CPEB1 specifi

SUBMITTER: Yin J 

PROVIDER: S-EPMC4196161 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature