CD271 is a functional and targetable marker of tumor-initiating cells in head and neck squamous cell carcinoma.

ABSTRACT: Tumor-initiating cells (TICs) in squamous cell carcinoma of the head and neck (SCCHN) are best characterized by their surface expression of CD44. Although there is great interest in identifying strategies to target this population, no marker of these cells has been found to be functionally active. Here, we examined the expression of the purported marker of normal human oral epithelial stem cells, CD271. We show that CD271 expression is restricted to a subset of the CD44+ cells. Using xenograft assays, we show that the CD44+CD271+ subpopulation contains the most tumorigenic cells. Loss of CD271 function results in a block in the G2-M phase of the cell cycle and a profound negative impact on the capacity of these cells to initiate tumor formation in vivo. Incubation with recombinant NGF resu

SUBMITTER: Murillo-Sauca O 

PROVIDER: S-EPMC4196168 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature