A generic cycling hypoxia-derived prognostic gene signature: application to breast cancer profiling.

ABSTRACT:

Background

Temporal and local fluctuations in O2 in tumors require adaptive mechanisms to support cancer cell survival and proliferation. The transcriptome associated with cycling hypoxia (CycHyp) could thus represent a prognostic biomarker of cancer progression.

Method

We exposed 20 tumor cell lines to repeated periods of hypoxia/reoxygenation to determine a transcriptomic CycHyp signature and used clinical data sets from 2,150 breast cancer patients to estimate a prognostic Cox proportional hazard model to assess its prognostic performance.

Results

The CycHyp prognostic potential was validated in patients independently of the receptor status of the tumors. The discriminating capacity of the CycHyp signature was further increased in the ER+ HER2- patient populations

SUBMITTER: Boidot R 

PROVIDER: S-EPMC4196175 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature