Dedifferentiation and substitute strategy: deconstructing the processing-speed impairment in schizophrenia.

ABSTRACT:

Background

Recent research has identified impairment in processing speed, measured by the digit-symbol substitution task, as central to the cognitive deficit in schizophrenia. However, the underlying cognitive correlates of this impairment remain unknown.

Methods

A sample of cases (N=125) meeting DSM-IV criteria for schizophrenia and a sample of community controls (N=272) from the same geographical area completed a set of putative measures of processing-speed ability to which we implemented confirmatory factor and structural regression modelling in order to elucidate the latent structure of processing speed. Next, we tested the degree to which the structural and relational portions of the model were equal across groups.

Results

Processing-speed ability was best define

SUBMITTER: Knowles EE 

PROVIDER: S-EPMC4196269 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature