Common mutations in BRCA1 and BRCA2 do not contribute to early prostate cancer in Jewish men.

ABSTRACT:

Background

Families with a high incidence of hereditary breast cancer, and subsequently shown to have terminating mutations in BRCA1 or BRCA2, appear to have a higher incidence of prostate cancer among male relatives. We aimed to determine whether the common germline mutations of BRCA1 or BRCA2 in Ashkenazi Jewish men predisposed them to prostate cancer.

Methods

We examined genomic DNA from 83 (for BRCA1 185delAG) or 82 (for BRCA2 6174delT) Ashkenazi Jewish prostate cancer patients, most of whom were treated at a relatively young age, for the most common germline mutation in each gene seen in the Ashkenazi population.

Results

Our study should have been able to detect a 4-5-fold increase in the risk of prostate cancer due to mutation of BRCA1 or BRCA2. However, only on

SUBMITTER: Nastiuk KL 

PROVIDER: S-EPMC4196372 | biostudies-literature | 1999 Aug

REPOSITORIES: biostudies-literature