Genome-wide association study of medication adherence in chronic diseases in the korean population.

ABSTRACT: Medication adherence is generally defined as the extent of voluntary cooperation of a patient in taking medicine as prescribed. Adherence to long-term treatment with chronic disease is essential for reducing disease comorbidity and mortality. However, medication non-adherence in chronic disease averages 50%. This study was conducted a genome-wide association study to identify the genetic basis of medication adherence. A total of 235 medication non-adherents and 1,067 medication adherents with hypertension or diabetes were used from the Korean Association Resource project data according to the self-reported treatment status of each chronic disease, respectively. We identified four single nucleotide polymorphisms with suggestive genome-wide association. The most significant single nucleotide

SUBMITTER: Seo I 

PROVIDER: S-EPMC4196376 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature