Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients.

ABSTRACT:

Aims

Islet amyloid is a hallmark in type 2 diabetic subjects, but its implication in clinical features and development of islet pathology is still unclear.

Methods

From 118 autopsy cases with type 2 diabetes, 26 cases with islet amyloid deposition (DA+) were selected. Twenty diabetic subjects without obvious amyloid deposition (DA-) matched for the age and diabetes duration and 20 non-diabetic subjects (ND) served for comparison. We examined the severity of amyloid deposition and its relationships with population of endocrine cells, expression of cell damage markers or macrophage infiltration. Correlation of clinical profile with islet pathology was also sought on the subset of the investigated patients.

Results

β-Cell volume density was nearly 40% less in DA+ and 20%

SUBMITTER: Kamata K 

PROVIDER: S-EPMC4196506 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature