Shared genetic pathways contribute to the tolerance of endogenous and low-dose exogenous DNA damage in yeast.

ABSTRACT: DNA damage that escapes repair and blocks replicative DNA polymerases is tolerated by bypass mechanisms that fall into two general categories: error-free template switching and error-prone translesion synthesis. Prior studies of DNA damage responses in Saccharomyces cerevisiae have demonstrated that repair mechanisms are critical for survival when a single, high dose of DNA damage is delivered, while bypass/tolerance mechanisms are more important for survival when the damage level is low and continuous (acute and chronic damage, respectively). In the current study, epistatic interactions between DNA-damage tolerance genes were examined and compared when haploid yeast cells were exposed to either chronic ultraviolet light or chronic methyl methanesulfonate. Results demonstrate that genes as

SUBMITTER: Lehner K 

PROVIDER: S-EPMC4196610 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature