Extracellular matrix and cytochrome P450 gene expression can distinguish steatohepatitis from steatosis in mice.

ABSTRACT: One of the main questions regarding nonalcoholic fatty liver disease is the molecular background of the transition from simple steatosis (SS) to the inflammatory and fibrogenic condition of steatohepatitis (NASH). We examined the gene expression changes during progression from histologically normal liver to SS and NASH in models of obesity caused by hyperphagia or a high-fat diet. Microarray-based analysis revealed that the expression of 1445 and 264 probe sets was changed exclusively in SS and NASH samples, respectively, and 1577 probe sets were commonly altered in SS and NASH samples. Functional annotations indicated that transcriptome alterations that were common for NASH and SS, as well as exclusive for NASH, involved extracellular matrix (ECM)-related processes, although they differed

SUBMITTER: Hennig EE 

PROVIDER: S-EPMC4196652 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature