Injectable solid peptide hydrogel as a cell carrier: effects of shear flow on hydrogels and cell payload.

ABSTRACT: β-hairpin peptide-based hydrogels are a class of injectable solid hydrogels that can deliver encapsulated cells or molecular therapies to a target site via syringe or catheter injection as a carrier material. These physical hydrogels can shear-thin and consequently flow as a low-viscosity material under a sufficient shear stress but immediately recover back into a solid upon removal of the stress, allowing them to be injected as preformed gel solids. Hydrogel behavior during flow was studied in a cylindrical capillary geometry that mimicked the actual situation of injection through a syringe needle in order to quantify effects of shear-thin injection delivery on hydrogel flow behavior and encapsulated cell payloads. It was observed that all β-hairpin peptide hydrogels investigated displaye

SUBMITTER: Yan C 

PROVIDER: S-EPMC4196894 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature