Onecut1 and Onecut2 play critical roles in the development of the mouse retina.

ABSTRACT: The entire repertoire of intrinsic factors that control the cell fate determination process of specific retinal neurons has yet to be fully identified. Single cell transcriptome profiling experiments of retinal progenitor cells revealed considerable gene expression heterogeneity between individual cells, especially among different classes of transcription factors. In this study, we show that two of those factors, Onecut1 and Onecut2, are expressed during mouse retinal development. Using mice that are deficient for each of these transcription factors, we further demonstrate a significant loss (∼70-80%) of horizontal cells in the absence of either of these proteins, while the other retinal cells appear at normal numbers. Microarray profiling experiments performed on knockout retinas revealed

SUBMITTER: Goetz JJ 

PROVIDER: S-EPMC4196951 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature