Evaluation and comparison of the potential of two ferritins as anti-tick vaccines against Haemaphysalis longicornis.

ABSTRACT:

Background

Tick control is an essential aspect of controlling the spread of tick-borne diseases affecting humans and animals, but it presently faces several challenges. Development of an anti-tick vaccine is aimed at designing cost-effective and environmentally friendly protection against ticks and tick-borne diseases as an alternative to the use of chemical acaricides. A single vaccine from the tick midgut protein Bm86 is currently available for field applications, but its efficacy is limited to only some tick species. Identification of candidate vaccine antigens that can affect multiple tick species is highly desirable. The hard tick Haemaphysalis longicornis has two kinds of the iron-binding protein ferritin (HlFER), an intracellular HlFER1 and a secretory HlFER2, and RNA interf

SUBMITTER: Galay RL 

PROVIDER: S-EPMC4197249 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature