High levels of mannose-binding lectin are associated with lower pulse wave velocity in uraemic patients.

ABSTRACT:

Background

Uraemia is associated with a highly increased risk of cardiovascular disease. Mannose-binding lectin (MBL) has been shown to be involved in cardiovascular pathophysiology and a protective effect of MBL is suggested. The purpose of the present study was to evaluate a potential impact of MBL on vascular parameters in uraemic patients.

Methods

A cohort of 98 patients with end stage renal disease (ESRD) awaiting kidney transplantation had pulse wave velocity (PWV) and augmentation index (AIX) examined by tonometry and endothelial dependent flow-mediated (FMD) and endothelial independent nitroglycerin-induced (NID) dilatory capacities of the brachial artery measured by ultrasound. An oral glucose tolerance test (OGTT) was performed and serum levels of MBL were measured

SUBMITTER: Hornum M 

PROVIDER: S-EPMC4197330 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature