Spatial pattern of cell geometry and cell-division orientation in zebrafish lens epithelium.

ABSTRACT: Cell proliferation is a key regulator of tissue morphogenesis. We examined cell proliferation and cell division in zebrafish lens epithelium by visualizing cell-cycle phases and nuclear positions, using fluorescent-labeled geminin and histone proteins. Proliferation was low in the anterior region of lens epithelium and higher in the marginal zone anterior to the equator, suggesting that the proliferation zone, called the germinative zone, is formed in zebrafish lens. Interestingly, cell-division orientation was biased longitudinally in the anterior region, shifted from longitudinal to circumferential along the anterior-posterior axis of lens sphere, and was biased circumferentially in the peripheral region. These data suggest that cell-division orientation is spatially regulated in zebrafi

SUBMITTER: Mochizuki T 

PROVIDER: S-EPMC4197447 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature