Large inter-individual variation in isoflavone plasma concentration limits use of isoflavone intake data for risk assessment.

ABSTRACT:

Background/objectives

Isoflavones are present in soy foods and soy-based supplements. Despite low plasma isoflavone concentrations in the general Western population, concentrations in supplement users exceed those suggested to be beneficial for health in Asian populations, raising concerns for adverse effects. To aid risk assessment, quantification of the relation between isoflavone intake and plasma concentrations is essential.

Subjects/methods

Plasma samples were collected from postmenopausal women in three placebo-controlled crossover studies with 8-week periods for supplements (two studies, ~100 mg isoflavones/day, n=88) or 4-week periods for soy foods (one study, ~48 mg isoflavones/day, n=15). Plasma isoflavone concentrations (daidzein, equol, genistein and glycitein) w

SUBMITTER: van der Velpen V 

PROVIDER: S-EPMC4197455 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature