Energy-based analysis of biochemical cycles using bond graphs.

ABSTRACT: Thermodynamic aspects of chemical reactions have a long history in the physical chemistry literature. In particular, biochemical cycles require a source of energy to function. However, although fundamental, the role of chemical potential and Gibb's free energy in the analysis of biochemical systems is often overlooked leading to models which are physically impossible. The bond graph approach was developed for modelling engineering systems, where energy generation, storage and transmission are fundamental. The method focuses on how power flows between components and how energy is stored, transmitted or dissipated within components. Based on the early ideas of network thermodynamics, we have applied this approach to biochemical systems to generate models which automatically obey the laws of

SUBMITTER: Gawthrop PJ 

PROVIDER: S-EPMC4197480 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature