P120-catenin-dependent junctional recruitment of Shroom3 is required for apical constriction during lens pit morphogenesis.

ABSTRACT: Apical constriction (AC) is a widely utilized mechanism of cell shape change whereby epithelial cells transform from a cylindrical to conical shape, which can facilitate morphogenetic movements during embryonic development. Invertebrate epithelial cells undergoing AC depend on the contraction of apical cortex-spanning actomyosin filaments that generate force on the apical junctions and pull them toward the middle of the cell, effectively reducing the apical circumference. A current challenge is to determine whether these mechanisms are conserved in vertebrates and to identify the molecules responsible for linking apical junctions with the AC machinery. Utilizing the developing mouse eye as a model, we have uncovered evidence that lens placode AC may be partially dependent on apically posit

SUBMITTER: Lang RA 

PROVIDER: S-EPMC4197547 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature