MicroRNA-421 Dysregulation is Associated with Tetralogy of Fallot.

ABSTRACT: The importance of microRNAs for maintaining stability in the developing vertebrate heart has recently become apparent. In addition, there is a growing appreciation for the significance of microRNAs in developmental pathology, including the formation of congenital heart defects. We examined the expression of microRNAs in right ventricular (RV) myocardium from infants with idiopathic tetralogy of Fallot (TOF, without a 22q11.2 deletion), and found 61 microRNAs to be significantly changed in expression in myocardium from children with TOF compared to normally developing comparison subjects (O'Brien et al. 2012). Predicted targets of microRNAs with altered expression were enriched for gene networks that regulate cardiac development. We previously derived a list of 229 genes known to be critica

SUBMITTER: Bittel DC 

PROVIDER: S-EPMC4197626 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature