Human genomic regions with exceptionally high levels of population differentiation identified from 911 whole-genome sequences.

ABSTRACT:

Background

Population differentiation has proved to be effective for identifying loci under geographically localized positive selection, and has the potential to identify loci subject to balancing selection. We have previously investigated the pattern of genetic differentiation among human populations at 36.8 million genomic variants to identify sites in the genome showing high frequency differences. Here, we extend this dataset to include additional variants, survey sites with low levels of differentiation, and evaluate the extent to which highly differentiated sites are likely to result from selective or other processes.

Results

We demonstrate that while sites with low differentiation represent sampling effects rather than balancing selection, sites showing extremely high

SUBMITTER: Colonna V 

PROVIDER: S-EPMC4197830 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature