Cognitive impairment in lacunar strokes: the SPS3 trial.

ABSTRACT:

Objective

Lacunar strokes are a leading cause of cognitive impairment and vascular dementia. However, adequate characterization of cognitive impairment is lacking. The aim of this study was to estimate the prevalence and characterize the neuropsychological impairment in lacunar stroke patients.

Methods

All English-speaking participants in the Secondary Prevention of Small Subcortical Strokes (SPS3) trial (National Clinical Trial 00059306) underwent neuropsychological testing at baseline. Raw scores were converted to z scores using published norms. Those with impairment (z ≤ -1.5) in memory and/or nonmemory domains were classified as having mild cognitive impairment (MCI).

Results

Among the 1,636 participants, average z scores on all tests were < 0, with the largest de

SUBMITTER: Jacova C 

PROVIDER: S-EPMC4198173 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature