The Fusarium graminearum genome reveals more secondary metabolite gene clusters and hints of horizontal gene transfer.

ABSTRACT: Fungal secondary metabolite biosynthesis genes are of major interest due to the pharmacological properties of their products (like mycotoxins and antibiotics). The genome of the plant pathogenic fungus Fusarium graminearum codes for a large number of candidate enzymes involved in secondary metabolite biosynthesis. However, the chemical nature of most enzymatic products of proteins encoded by putative secondary metabolism biosynthetic genes is largely unknown. Based on our analysis we present 67 gene clusters with significant enrichment of predicted secondary metabolism related enzymatic functions. 20 gene clusters with unknown metabolites exhibit strong gene expression correlation in planta and presumably play a role in virulence. Furthermore, the identification of conserved and over-repre

SUBMITTER: Sieber CM 

PROVIDER: S-EPMC4198257 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature