Role of arterial telomere dysfunction in hypertension: relative contributions of telomere shortening and telomere uncapping.

ABSTRACT:

Objective

Telomere shortening in arteries could lead to telomere uncapping and cellular senescence, which in turn could promote the development of hypertension.

Methods and results

To assess the novel role of arterial telomere dysfunction in hypertension, we compared mean telomere length (qPCR), telomere uncapping (serine 139 phosphorylated histone γ-H2A.X (γ-H2) localized to telomeres: ChIP), and tumor suppressor protein p53 (P53)/cyclin-dependent kinase inhibitor 1A (P21)-induced senescence (P53 bound to P21 gene promoter: ChIP) in arteries from 55 age-matched hypertensive and nonhypertensive individuals. Arterial mean telomere length was not different in hypertensive patients compared with nonhypertensive individuals (P = 0.29). Arterial telomere uncapping and P53/P21-ind

SUBMITTER: Morgan RG 

PROVIDER: S-EPMC4198301 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature