Pregnane X receptor and drug-induced liver injury.

ABSTRACT:

Introduction

The liver plays a central role in transforming and clearing foreign substances. The continuous exposure of the liver to xenobiotics sometimes leads to impaired liver function, referred to as drug-induced liver injury (DILI). The pregnane X receptor (PXR) tightly regulates the expression of genes in the hepatic drug-clearance system and its undesired activation plays a role in DILI.

Areas covered

This review focuses on the recent progress in understanding PXR-mediated DILI and highlights the efforts made to assess and manage PXR-mediated DILI during drug development.

Expert opinion

Future efforts are needed to further elucidate the mechanisms of PXR-mediated liver injury, including the epigenetic regulation and polymorphisms of PXR. Novel in vitro models c

SUBMITTER: Wang YM 

PROVIDER: S-EPMC4198438 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature