Evaluating the risk of ovarian cancer before surgery using the ADNEX model to differentiate between benign, borderline, early and advanced stage invasive, and secondary metastatic tumours: prospective multicentre diagnostic study.

ABSTRACT:

Objectives

To develop a risk prediction model to preoperatively discriminate between benign, borderline, stage I invasive, stage II-IV invasive, and secondary metastatic ovarian tumours.

Design

Observational diagnostic study using prospectively collected clinical and ultrasound data.

Setting

24 ultrasound centres in 10 countries.

Participants

Women with an ovarian (including para-ovarian and tubal) mass and who underwent a standardised ultrasound examination before surgery. The model was developed on 3506 patients recruited between 1999 and 2007, temporally validated on 2403 patients recruited between 2009 and 2012, and then updated on all 5909 patients.

Main outcome measures

Histological classification and surgical staging of the mass.

Results

Th

SUBMITTER: Van Calster B 

PROVIDER: S-EPMC4198550 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature