Acute lysine supplementation does not improve hepatic or peripheral insulin sensitivity in older, overweight individuals.

ABSTRACT:

Context

Lysine supplementation may have a positive influence on the regulation of glucose metabolism but it has not been tested in the geriatric population.

Objective

We evaluated the impact of acute lysine supplementation using three randomized experimental scenarios: 1) oral glucose alone (control), 2) oral glucose and low-dose lysine (2 grams), and oral glucose and high dose lysine (5 grams) lysine in 7 older (66 ± 1 years/age), overweight/obese (BMI = 28 ± 2 kg/m(2)) individuals.

Methods

We utilized a dual tracer technique (i.e., [6,6-(2)H2] glucose primed constant infusion and 1-[(13)C] glucose oral ingestion) during an oral glucose tolerance test (OGTT) to examine differences in hepatic and peripheral insulin sensitivity under all three scenarios.

Results

SUBMITTER: Kim IY 

PROVIDER: S-EPMC4198625 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature