Characterization of a mouse recombination hot spot locus encoding a novel non-protein-coding RNA.

ABSTRACT: Our current knowledge of recombination hot spot activity in mammalian systems implicates a role for both the primary DNA sequence and the nature of the chromatin domain around it. In mice, the only recombination hot spots mapped to date have been confined to a cluster within the major histocompatibility complex (MHC) region. We present a high resolution analysis of a new recombination hot spot in the mouse genome which maps to mouse chromosome 8 C-D. Haplotype diversity analysis across 40 different strains of mice has enabled us to map recombination breakpoints to a 1-kb interval. This hot spot has a recombination intensity that is 10- to 100-fold above the genome average and has a mean gene conversion tract length of 371 bp. This meiotically active locus happens to be flanked by a transcr

SUBMITTER: Nishant KT 

PROVIDER: S-EPMC419864 | biostudies-literature | 2004 Jun

REPOSITORIES: biostudies-literature