Association of the interleukin-22 genetic polymorphisms with ulcerative colitis.

ABSTRACT:

Background

Interleukin-22 (IL-22) is a member of the IL-10 family of anti-inflammatory cytokines that mediates epithelial immunity. IL-22 expression was found to be increased in patients with ulcerative colitis (UC). Whether genetic polymorphisms of IL-22 also influence UC risk is still unknown. The purpose of this study was to investigate the association between the IL-22 gene polymorphisms (-429 C/T, +1046 T/A and +1995 A/C) and the risk of UC in Chinese Han patients.

Methods

This hospital-based case-control study comprised 180 patients with UC and 180 age- and gender-matched controls. Genotypes of 3 common polymorphisms of the IL-22 gene were determined by fluorogenic 5' exonuclease assays (TaqMan).

Results

Patients with UC had a significantly higher frequency of I

SUBMITTER: Chi HG 

PROVIDER: S-EPMC4198677 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature