Recombinant human erythropoietin in amyotrophic lateral sclerosis: a pilot study of safety and feasibility.

ABSTRACT:

Background and purpose

It has been shown that erythropoietin is neuroprotective in animal models of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). The aim of this study was to determine the safety and feasibility of repetitive high-dose recombinant human erythropoietin (rhEPO) therapy in ALS patients.

Methods

Two consecutive studies were conducted. We first recruited 26 subjects for an initial single-arm safety study. After a lead-in period of 3 months to assess the disease progression, rhEPO was infused intravenously (35,000 IU) once per month for 3 months, and the subjects were followed for an additional 3 months. The ALS Functional Rating Scale-Revised (ALSFRS-R) was used for clinical assessment. After confirming the safety of rhEPO, 60 subjects

SUBMITTER: Kim HY 

PROVIDER: S-EPMC4198716 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature