Differential expression of genes involved in the epigenetic regulation of cell identity in normal human mammary cell commitment and differentiation.

ABSTRACT: The establishment and maintenance of mammary epithelial cell identity depends on the activity of a group of proteins, collectively called maintenance proteins, that act as epigenetic regulators of gene transcription through DNA methylation, histone modification, and chromatin remodeling. Increasing evidence indicates that dysregulation of these crucial proteins may disrupt epithelial cell integrity and trigger breast tumor initiation. Therefore, we explored in silico the expression pattern of a panel of 369 genes known to be involved in the establishment and maintenance of epithelial cell identity and mammary gland remodeling in cell subpopulations isolated from normal human mammary tissue and selectively enriched in their content of bipotent progenitors, committed luminal progenitors, and

SUBMITTER: Coradini D 

PROVIDER: S-EPMC4198753 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature